Frequency of Tinnitus in Hypertensive Patients
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https://doi.org/10.5281/zenodo.11532037Keywords:
Tinnitus, Hypertension, Vitamin D, Vitamin B12Abstract
Tinnitus (ringing in the ears) is a conscious perception of sound sensation that occurs without any external stimulus or external source, and is described by patients as ringing, crackling, hissing, or rarely, musical sound. Tinnitus is associated with many factors, especially hypertension, which is a multifactorial clinical condition. The aim of our study is to investigate the frequency of tinnitus in hypertension patients and discuss it in the light of the relevant literature.
In our study, the frequency of tinnitus was investigated in 63 adult patients diagnosed with hypertension between January 2020 and June 2023. In addition to routine laboratory and radiological examinations, the patients' vitamin D, vitamin B12, magnesium and folate levels were also measured. The t test was used for statistical analysis, and p values less than 0.05 were considered statistically significant.
There were 30 (47.61%) female and 33 (52.38%) male patients included in the study. A total of 15 (23.8%) patients, eight males and seven females, had tinnitus. The average age of patients with tinnitus was 68.66±9.49 years and the average age of patients without tinnitus was 62.39±9.89 years. The mean age was significantly higher in hypertensive patients with tinnitus (p<0.05). The average vitamin B12 level was significantly lower in hypertensive patients with tinnitus (p<0.05). Eight of 15 patients with tinnitus (53.33%) and 15 of 48 patients without tinnitus (31.24%) were diabetic.
In our study, a very high tinnitus frequency of 23.8% was observed in hypertensive patients, and the relationship between tinnitus and hypertension is striking, especially in our elderly patients. However, since hypertension and tinnitus are mutually related, all cases with tinnitus, including young people, should be evaluated for hypertension, diabetes and dyslipidemia. Additionally, deficiencies in vitamin D and vitamin B12 levels should be avoided.
References
Avşar E, Adaiçi M. Yaşlı Bireylerde Tinnutus ve Hipertansiyon Arasındaki İlişki. Geriatrik Bilim Derg 2021;4(2):66-71.
Azmat S, Mumtaz N, Saqulain G. Prevalence of tinnitus in hypertensive patients: In a clinical setup. J Med Allied Sci 2 0 2 0 ; 1 0 ( 2 ) : 6 2 - 6 6.
Baguley D, McFerran D, Hall D. Tinnitus. The Lancet.2013; 382(9904): 1600-1607.
Benevides W. Otorrinolaringologista. Rio de Janeiro: Cultura Médica. 1997.
Berkiten G, Yildirim G, Topaloglu I, Ugras H. Vitamin B12 levels in patients with tinnitus and effectiveness of vitamin B12 treatment on hearing threshold and tinnitus. B-ent. 2013;9(2):111–6.
Borghi C, Brandolini C, Prandin MG, Dormi A, Modugno GC, Pirodda A. Prevalence of tinnitus in patients with hypertension and the impact of different anti-hypertensive drugs on the incidence of tinnitus: A prospective, single-blind, observational study. Curr Ther Res Clin Exp. 2005; 66(5):420-32.
Dadgarnia M, Mandegari M, Zand V, Vaziribozorg S, Zare-Zardini H, Mousaviyazdi K, et al. The effect of vitamin B12 on idiopathic tinnitus. Am J Otolaryngol. 2023;45(1):104028. doi: 10.1016/j.amjoto.2023.104028. Epub ahead of print. PMID: 37647778.
Dehkordi MA, Abolbashari S, Taheri R, Einolghozati S. Efficacy of gabapentin on subjective idiopathic tinnitus: A randomized, doubleblind, placebo-controlled trial. Ear Nose Throat J 2011;90:150–8.
Elsayed SMA. Egyptian Journal of Ear Nose Throat and Allied Sciences. 2021;22(1):1-4.
Ferreira LMDBM, Ramos Júnior AN, Mendes EP. Characterization of tinnitus in the elderly and its possible related disorders. Revista Brasileira de Otorrinolaringologia. 2009; 75: 249-255.
Figueiredo RR, de Azevedo AA, de Oliveira Penido N. Tinnitus and arterial hypertension: a systematic review. European Archives of Oto-RhinoLaryngology. 2015; 272(11), 3089-3094.
Figueiredo RR, Azevedo AA, Penido NDO. Positive association between tinnitus and arterial hypertension. Frontiers in neurology. 2016; 7: 171.
Franklin SS, Larson MG, Khan SA, et al. Does the relation of blood pressure to coronary heart disease risk change with aging?. The Framingham Heart Study. Circulation. 2001;103(9):1245-1249.
Gibrin PCD, Melo JJ, Marchiori LL, de M. Prevalence of tinnitus complaints and probable association with hearing loss, diabetes mellitus and hypertension in elderly. Codas 2013;25:176–80.
Hoffman HJ, Red GW. Epidemiology of tinnitus. In: Snow Jr JB, ed. Tinnitus Theory and Management. BC Decker Inc, London, 2004:16-41.
Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008; 87:1080S–1086S.
Kalyoncu ZB, Pars H, Bora-Günes N, Karabulut E, Aslan D. A systematic review of nutrition-based practices in prevention of hypertension among healthy young. Turk J Pediatr (2014) 56(4):335–46.
Keda, K, Kobayashi, T, Itoh Z, Kusakari J, Takasaka T. Evaluation of vitamin D metabolism in patients with bilateral sensorineural hearing loss. Am. J. Otol.1989,10, 11–13.
Lasisi AO, Abiona T, Gureje O. Tinnitus in the elderly: Profile, correlates, and impact in the Nigerian Study of Ageing. Otolaryngology—Head and Neck Surgery. 2010; 143(4): 510-515.
Lewis JE, Stephens SDG, McKenna L. Tinnitus and suicide. Clin Otolaryngol Allied Sci. 1994; 19: 50-54).
Lloyd-Jones DM, Evans JC, Levy D. Hypertension in adults across the age spectrum: current outcomes and control in the community. JAMA. 2005;294(4):466-472.
Nobre F, Amodeo C, Consolim-Colombo FA. VI Diretrizes Brasileiras de Hipertensão. Rev Bras Hipert (2010) 17(1):7–60.
Oliveros E, Patel H, Kyung S, Fugar S, Goldberg A, Madan N, Williams KA. Hypertension in older adults: Assessment, management, and challenges. Clin Cardiol. 2020 Feb;43(2):99-107. doi: 10.1002/clc.23303. Epub 2019 Dec 11. PMID: 31825114; PMCID: PMC7021657.
Patel SD, Patel S, Finberg A, Shah VN, Mittal R, Eshraghi AA. Association Between Tinnitus and Hypertension: A Cross-Sectional Analysis of the National Health and Nutrition Examination Survey. Otol Neurotol. 2022;43(7):766-772. doi: 10.1097/MAO.0000000000003579. Epub 2022 Jul 4. PMID: 35802039.
Paulose-Ram R, Gu Q, Kit B. Characteristics of U.S. adults with hypertension who are unaware of their hypertension, 2011–2014. NCHS Data Brief 2017;1–8.
Sarhan NA, Abdelsalam AMAEM. Prevalence of idiopathic tinnitus in patients with hypertension and its impact on quality of life. Life Science Journal. 2016; 13(1): 9-15.
Shemesh Z, Attias J, Ornan M, Shapira N, Shahar A. Vitamin B12 deficiency in patients with chronic-tinnitus and noise-induced hearing loss. Am J Otolaryngol 1993;14(2):94–9.
Sözen Gencer N, Akçiçek SF. Yaşlıda hipertansiyon. Saraç ZF, Savaş S, editörler. Geriatrik Endokrinoloji. 1. Baskı. Ankara: Türkiye Klinikleri; 2022. p.16-23.
Tabassum M, Rehman AU, Ashraf T, Tahira A, Ali S, Nomani T. Frequency Of Tinnitus In Hypertensive Patients, A Cross Sectional Survey. JRLMC. 2021;1(1): 05-07.
Taneja MK, Vivek Taneja. Role of vitamin D in prevention of deafness. Indian J otology.2012; 18(2):55–57. doi:10.4103/0971-7749.100692.
Tuncer Ü, Sürmelioğlu Ö. Tinnitusta Patofizyoloji. Turkiye Klinikleri J E.N.T.-Special Topics. 2010;3(2):6-10.
Webber G, Heilborn JD, Chamorro Jimenez Cl, Hammarsjo A, Torma H, Stahle M. Vitamin D induces the antimicrobial protein hCAP18 in human skin. J Invest Dermatal. 2005; 124:1080–1082.
Yang P, Ma W, Zheng Y, Yang H, Lin H. A systematic review and meta-analysis on the association between hypertension and tinnitus. Int J Hypertens. 2015;2015:583493. DOI:10.1155/2015/583493.
Zachariah M, Idiculla J, Begum K. Serum Vitamin B12 Levels among Type 2 Diabetic Patients Maintained on Metformin Based Oral Anti-Diabetic Drugs-An Observational Study. The Indian Journal of Nutrition and Dietetics. 2020; 57(2): 154-163.
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