Nigella sativa yağı metabolik sendroma bağlı hasarı iyileştirir
Özet Görüntüleme: 131
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DOI:
https://doi.org/10.5281/zenodo.8416168Anahtar Kelimeler:
BDNF, Cytokines, Metabolic syndrome, Nigella sativa oil, Neurotransmitter, Oxidative stressÖzet
Metabolik sendrom (MetS), oksidatif stres ve hücresel hasarın yanı sıra yağ dokusunda iltihaplanmaya neden olur. Nigella sativa yağının, sıçanlarda aşırı fruktoz alımının neden olduğu MetS üzerindeki koruyucu etkilerini ve biyokimyasal mekanizmalarını araştırmayı amaçladık. Çalışmada 21 erkek Sprague-Dawley sıçanı kullanıldı. Sıçanlar; kontrol grubu, metabolik sendrom grubu ve nigella sativa yağı grubu olarak gruplara ayrıldı. Kontrol grubundaki sıçanlara sadece musluk suyu ve pelet yem verilirken, deney grubundaki sıçanlara % 10 fruktoz içeren musluk suyu ve 10 hafta boyunca peletlenmiş diyet uygulandı. Nigella sativa grubuna 4 hafta boyunca oral yol ile günde 0.1 ml nigella sativa yağı verildi. Çalışma tamamlandıktan sonra sıçanlar dekapite edildi ve serum biyokimya parametreleri, BDNF, nörotransmiterler, sitokin ve antioksidan seviyeleri ölçüldü. Metabolik sendromla birlikte artan serum glukoz, insülin, insülin direnci (HOMA-IR) ve lipid profili düzeyleri nigella sativa yağı ile anlamlı şekilde azaldı. Nigella sativa yağı (NSO), fruktoz ile indüklenen metabolik sendrom sıçan modelinde beyin kaynaklı nörotrofik faktör (BDNF), 5-hidroksiindol asetik asit (5-HIAA), 5-hidroksitriptamin (5-HT), nor-adrenalin (NA), adrenalin (AD), dopamin (DA), tümör nekroz faktörü-α (Tnf-α), interlökin-6 (IL-6), total antioksidan durum (TAS) ve total oksidan durum (TOS) parametrelerini düzenlemiştir. NSO'nun, metabolik sendromun neden olduğu oksidatif stres ve inflamatuar hasarın gelişmesini önlemede ve nörotransmiterlerin karmaşık mekanizmalarını aydınlatmada umut verici bir uygulama seçeneği olduğu tespit edildi.
Referanslar
Akbıyık B, Eğritağ HE, Taşçı FD (2022) Some hormones playing the role in the pathogenesis of metabolic syndrome. Current Perspectives on Health Sciences 3(1): 16-22
Ali BH, Blunden G (2003) Pharmacological and toxicological properties of Nigella sativa. Phytother Res 17: 299–305
Barquilla PC, Pagano ES, Ortega VJ et al (2014) Melatonin normalizes clinical and biochemical parameters of mild in fl ammation in diet-induced metabolic syndrome in rats. J. Pineal Res 57:280–290.
Bouasla I, Bouasla A, Boumendjel A et al (2014) Nigella sativa Oil Reduces Aluminium Chloride-Induced Oxidative Injury in Liver and Erythrocytes of Rats.Biol Trace Elem Res 62(1):252–261
Bradley JR (2008) TNF-mediated inflammatory disease. Jour of Pathol 214:149-60
Charrière G, Cousin B, Arnaud E et al (2003) Preadipocyte conversion to macrophage. Evidence of plasticity. J Biol Chem 278: 9850-9855
Chen J, Guo Y, Gui Y et al (2018) Physical exercise, gut, gut microbiota, and atherosclerotic cardiovascular diseases. Lipids in health and disease 17(1): 1-7
Cikman O, Taysi S, Gulsen MT et al (2015) The Radio-protective effects of Caffeic Acid Phenethyl Ester and Thymoquinone in rats exposed to total head irradiation. Wien Klin Wochenschr 127(1):103–108
Daba MH, Abdel-Rahman MS (1998) Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol Lett 95: 23-29
Dantzer R (2006) Cytokine, sickness behavior, and depression. Neurologic Clinics 24(3): 441–460.
Doğan AE (2019) Effect of metabolic syndrome and metabolic syndrome components on tumor aggressiveness in renal cell carcinoma. Ankara: Gazi University Faculty of Medicine 2019. 7
Er F (2017) The effect of quercetin administration and exercise in fructose-mediated metabolic syndrome model. Ankara: Gazi University Institute of Health Sciences 2017
Faul F, Erdfelder E, Lang AG et al (2007) G Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39 (2):175-91
Francis PT, Ramırez MJ, Lai MK (2010) Neurochemical basis for symptomatic treatment of Alzheimer’s disease. Neuropharmacology 59(4): 221–229
Georgy GS, Nassar N, Mansour HA et al (2013) Cerebrolysin Ameloriates Cognitive Deficits in Type III Diabetic Rats. Plos one 8(6):e64847
Goldstein BJ (2002) Insulin resistance as the care defect in type 2 diabetes mellitus. Am J Cardiol 90(3): 10-20
Haider S, Perveen T, Batool Z et al (2014) Age-related learning and memory deficits in rats: role of altered brain neurotransmitters, acetylcholinesterase activity and changes in antioxidant defense system. American Aging Association 36:1291–1302
Hohlfeld R, Kerschensteiner M, Stadelmann C et al (2000) The neuroprotective effect of inflammation: Implications for the thearpy of multple sclerosis. J. Neuroimmunal 107(2): 161- 166.
Kanter M (2008) Effects of Nigella sativa and its major constituent, Thymoquinone on sciatic nerves in exprimental Diabetic Neuropaty. Neurochen Res 33(1):87-96
Kim SE, Ko IG, Kim BK et al (2010) Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus. Exp Gerontol 45(5): 357–365.
Lastra G, Manrique CM, Hayden MR (2006) The role of beta-cell dysfunction in the cardiometabolic syndrome. J. Cardiometab. Syndr 1(1):41-6
Lesemann A, Reinel C, Hu¨hnchen P et al (2012) MPTP-induced hippocampal effects on serotonin, dopamine, neurotrophins, adult neurogenesis and depression-like behavior are partially influenced by fluoxetine in adult mice. Brain Res 145(7): 51–69
Lorenzo M, Fernández-Veledo S, Vila-Bedmar R et al (2008) Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes. J Anim Sci 86: 94-104
Mattehews DR, Hosker JP, Rudenski AS et al (1985) Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412-9
Menon PK, Muresanu DF, Sharma A et al (2012) Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals. CNS Neurol Disord Drug Targets 11(1): 40–49.
Merighi A, Salio C, Ghirri A et al (2008) BDNF as a pain modulator. Prog. Neurobiol 85(3): 297-317 .
Ono M, Itakura Y, Nonomura T et al (2000) Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice. Metabolism 49(1): 129–133
Opal SM, DePalo VA (2000) Anti-inflammatory cytokines. Chest J 117: 1162 -1172
Perveen T, Haider S, Zuberi NA et al (2014) Increased 5-HT Levels Following Repeated Administration of Nigella sativa L. (Black Seed) Oil Produce Antidepressant Effects in Rats Sci Pharm 82: 161–170
Perveen T, Hainder S (2013) Increased 5-HT Levels Following Repeated Administration of Nigella sativa Oil Produce Antidepressant Effects in Rats. Sci Pharm 82(1):161-70
Reddy SS, Ramatholisamma P, Karuna R et al (2009) Preventive effect of Tinospora cordifolia against high-fructose diet-induced insülin resistance and oxidative stress in male Wistar rats. Food Chem Toxicol 47: 2224-2229
Sánchez-Lozada LG, Tapia E, Jiménez A et al (2007) Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol 292 (1): 423-429
Venancio DP, Suchecki D (2015) Prolonged REM sleep restriction induces metabolic syndrome-related changes: Mediation by pro-inflammatory cytokines. Brain, Behavior, and Immunity 47: 109–117
Yan H, Mitschelen M, Bixler GV et al (2011) Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence. J Endocrinol 211(1): 27–37.
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Telif Hakkı (c) 2023 Euroasia Journal of Mathematics, Engineering, Natural & Medical Sciences
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