Nigella sativa yağı metabolik sendroma bağlı hasarı iyileştirir
Özet Görüntüleme: 126
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DOI:
https://doi.org/10.5281/zenodo.8416168Anahtar Kelimeler:
BDNF, Cytokines, Metabolic syndrome, Nigella sativa oil, Neurotransmitter, Oxidative stressÖzet
Metabolik sendrom (MetS), oksidatif stres ve hücresel hasarın yanı sıra yağ dokusunda iltihaplanmaya neden olur. Nigella sativa yağının, sıçanlarda aşırı fruktoz alımının neden olduğu MetS üzerindeki koruyucu etkilerini ve biyokimyasal mekanizmalarını araştırmayı amaçladık. Çalışmada 21 erkek Sprague-Dawley sıçanı kullanıldı. Sıçanlar; kontrol grubu, metabolik sendrom grubu ve nigella sativa yağı grubu olarak gruplara ayrıldı. Kontrol grubundaki sıçanlara sadece musluk suyu ve pelet yem verilirken, deney grubundaki sıçanlara % 10 fruktoz içeren musluk suyu ve 10 hafta boyunca peletlenmiş diyet uygulandı. Nigella sativa grubuna 4 hafta boyunca oral yol ile günde 0.1 ml nigella sativa yağı verildi. Çalışma tamamlandıktan sonra sıçanlar dekapite edildi ve serum biyokimya parametreleri, BDNF, nörotransmiterler, sitokin ve antioksidan seviyeleri ölçüldü. Metabolik sendromla birlikte artan serum glukoz, insülin, insülin direnci (HOMA-IR) ve lipid profili düzeyleri nigella sativa yağı ile anlamlı şekilde azaldı. Nigella sativa yağı (NSO), fruktoz ile indüklenen metabolik sendrom sıçan modelinde beyin kaynaklı nörotrofik faktör (BDNF), 5-hidroksiindol asetik asit (5-HIAA), 5-hidroksitriptamin (5-HT), nor-adrenalin (NA), adrenalin (AD), dopamin (DA), tümör nekroz faktörü-α (Tnf-α), interlökin-6 (IL-6), total antioksidan durum (TAS) ve total oksidan durum (TOS) parametrelerini düzenlemiştir. NSO'nun, metabolik sendromun neden olduğu oksidatif stres ve inflamatuar hasarın gelişmesini önlemede ve nörotransmiterlerin karmaşık mekanizmalarını aydınlatmada umut verici bir uygulama seçeneği olduğu tespit edildi.
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Telif Hakkı (c) 2023 Euroasia Journal of Mathematics, Engineering, Natural & Medical Sciences
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