COMPARISON OF SHORT AND LONG-TERM OUTCOMES OF REPAIRS DONE WITH CONVENTİONAL SURGICAL METHODS AND FIBRİN-BASED TISSUE ADHESIVES IN DUODENUM PERFORATION MODEL IN RATS

Abstract

Peptic ulcer (PU) defines the chronic wounds which develop in esophageal gastric and small intestinal mucosa that is exposed to acid-peptic activity. Fibrin-based tissue adhesives (FBTA) are used for reducing fistula rates both in treatment of perforation, a complication of PU disease and laparoscopic treatment of obese patients. This experimental study was conducted with the aim of investigating the influence of FBTA on wound healing in perforation, a complication of PU. Materials and Methods: A total of 72 Wistar albino rats were used in the study. The animals were allocated to three groups as Group 1 (primary repair), Group 2 (primary repair and omentoplasty) and Group 3 (repair with only FBTA). Wound bursting pressure (WBP) and tissue hydroxyproline level (HPL) were measured on days 4,7 and 22. A p level of <0.05 was accepted as statistically significant. Results: Levels of WBP were found to be higher in Group 1 and 2 as compared to Group 3 on day 4 (p<0.01). No significant difference was found among groups with regard to WBP on days 7 and 22 (p>0.05). Levels of HPL were found to be statistically significantly higher in Group 1 and 2 as compared to Group 3 on day 4 (p<0.05 and p<0.01). Conclusion: The FBTA is less reliable than conventional surgical methods when used alone in PU perforation surgery. It may be used for supporting the other surgical methods instead of being used alone.