Use of Platelet-Rich Fibrin in Veterinary Medicine
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https://doi.org/10.5281/zenodo.12827947Keywords:
Platelet-rich fibrin, veterinary medicine, PRF, rejenerative veterinary medicineAbstract
Regenerative veterinary medicine has become a popular field with a continuous transformation following human medicine. In veterinary medicine, the ever-increasing integration of domestic animals with social life, longer life expectancy, and the similarity between human medicine and veterinary medicine in this regard increase the popularity of regenerative veterinary medicine. Recently, platelet-rich products (such as platelet-rich fibrin [PRF]) used in regenerative medicine have also attracted attention in veterinary medicine. The reason why these platelet-derived products attract attention is that they contain a high concentration of bioactive molecules such as cytokines and growth factors that significantly affect tissue healing and regeneration. Platelet-rich fibrin belongs to the second generation of platelet concentrates intended for simplified preparation without biochemical blood processing. It is seen that platelet-rich fibrin, which can be used in the field of veterinary regenerative medicine, is a regenerative treatment option that can be easily used in both soft tissue injuries and hard tissue injuries. It should be known that platelet-rich fibrin is a very good treatment option in veterinary medicine due to its easy and fast preparation, tissue compatibility, no contamination risk, low cost, non-infectious, controlling inflammation, non-allergic, haemostasis effect, reproducibility, accelerating vascularisation and most importantly accelerating tissue healing.
References
Soares CS, Babo PS, Reis RL, Carvalho PP, Gomes ME. Platelet-derived products in veterinary medicine: a new trend or an effective therapy? Trends in Biotechnology. 2021; 39(3): 225-243.
Carr BJ and Canapp SO. Regenerative medicine for soft tissue injury & osteoarthritis. Today’s Veterinary Practice. 2016 July/August; 53-60.
Hatakeyama I, Marukawa E, Takahashi Y, Omura K. Effects of platelet-poor plasma, platelet-rich plasma, and platelet-rich fibrin on healing of extraction sockets with buccal dehiscence in dogs. Tissue Engineering Part A. 2014; 20(3-4): 874-82.
Masoudi EA, Ribas J, Kaushik G, Leijten J, Khademhosseini A. Platelet-rich blood derivatives for stem cell-based tissue engineering and regeneration. Current stem cell reports. 2016; 2: 33-42.
Martínez CE, Smith PC, Palma Alvarado VA. The influence of platelet-derived products on angiogenesis and tissue repair: a concise update. Frontiers in physiology. 2015; 6: 290.
Silva RF, Carmona JU, Rezende CM. Ultrastructural characteristics of fibrin clots from canine and feline platelet concentrates activated with calcium gluconate or calcium gluconate plus batroxobin. BMC Veterinary Research. 2013; 9: 1-6.
Carr BJ, Canapp Jr SO, Mason DR, Cox C, Hess T. Canine platelet-rich plasma systems: a prospective analysis. Frontiers in veterinary science. 2016; 2: 73.
Chung T-h, Baek D-s, Kim N, Park J-h, Park C. Topical allogeneic platelet-rich plasma treatment for a massive cutaneous lesion induced by disseminated intravascular coagulation in a toy breed dog. Irish veterinary journal. 2015; 68: 1-4.
Naik B, Karunakar P, Jayadev M, Marshal VR. Role of Platelet rich fibrin in wound healing: A critical review. Journal of Conservative Dentistry and Endodontics. 2013; 16(4): 284-293.
Isobe K, Watanebe T, Kawabata H, Kitamura Y, Okudera T, Okudera H, et al. Mechanical and degradation properties of advanced platelet-rich fibrin (A-PRF), concentrated growth factors (CGF), and platelet-poor plasma-derived fibrin (PPTF). International journal of implant dentistry. 2017; 3: 1-6.
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2006; 101(3): e37-e44.
Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, et al. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. Journal of Oral Implantology. 2014 Dec; 40(6): 679-689.
Jiménez-Aristizabal RF, López C, Álvarez ME, Giraldo C, Prades M, Carmona JU. Long-term cytokine and growth factor release from equine platelet-rich fibrin clots obtained with two different centrifugation protocols. Cytokine. 2017; 97: 149-155.
Soares CS, Babo PS, Faria S, Pires MA, Carvalho PP. Standardized Platelet-Rich Fibrin (PRF) from canine and feline origin: An analysis on its secretome pattern and architectural structure. Cytokine. 2021; 148: 155695.
Preeja C, Arun S. Platelet-rich fibrin: Its role in periodontal regeneration. The Saudi Journal for Dental Research. 2014; 5(2): 117-122.
Dohan Ehrenfest DM, Pinto NR, Pereda A, Jiménez P, Corso MD, Kang B-S, et al. The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors, and fibrin architecture of a leukocyte-and platelet-rich fibrin (L-PRF) clot and membrane. Platelets. 2018; 29(2): 171-184.
Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Yaprak E, Toker H, et al. A novel platelet concentrate: titanium‐prepared platelet‐rich fibrin. BioMed research international. 2014; 2014(1): 209548.
Ucak Turer O, Ozcan M, Alkaya B, Surmeli S, Seydaoglu G, Haytac MC. Clinical evaluation of injectable platelet‐rich fibrin with connective tissue graft for the treatment of deep gingival recession defects: A controlled randomized clinical trial. Journal of clinical periodontology. 2020 Jan; 47(1): 72-80.
Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009 Mar; 27(3): 158-167.
Dohan Ehrenfest DM, Andia I, Zumstein MA, Zhang CQ, Pinto NR, Bielecki T. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014 May 8; 4(1): 3-9.
Mamajiwala AS, Sethi KS, Raut CP, Karde PA, Mangle NM. Impact of different platelet-rich fibrin (PRF) procurement methods on the platelet count, antimicrobial efficacy, and fibrin network pattern in different age groups: an in vitro study. Clinical Oral Investigations. 2020; 24: 1663-1675.
Gupta V, Bains VK, Singh G, Mathur A, Bains R. Regenerative potential of platelet rich fibrin in dentistry: Literature review. Asian J Oral Health Allied Sci. 2011; 1(1): 23-31.
Knecht C, St Clair L. The radial-brachial paralysis syndrome in the dog. Journal of the American Veterinary Medical Association. 1969; 154(6): 653-656.
Anatolitou A, Kazakos G, Prassinos N. Peripheral nerve damage in companion animals. Hellenic Journal of Companion Animal Medicine. 2012; 1(2): 2-19.
Karabulut M.''Tavşanlarda Deneysel Sinir Hasarının İyileşmesi Üzerinde Trombositten Zengin Fibrin'in Etkisi''. Doktora Tezi. Elazığ: Fırat Üniversitesi, Sağlık Bilimleri Enstitüsü, Veterinerlik Cerrahisi Ana Bilim Dalı; 2023.
Karabulut M, Durmuş AS. Termal Deri Yanıkları ve Tedavileri. Editör: Keçeci H, Öztürk M. Sağlık Alanında Akademik Araştırma ve Değerlendirmeler. Ankara: İksad Yayınevi. 2022; 1: 211-236.
Sancak T.''İkinci Derece Yanık Yaralarının Sağaltımında Enjekte Edilebilen Trombositten Zengin Fibrin Kullanımının Termografik ve Histopatolojik Değerlendirilmesi: Tavşan Modeli''. Doktora Tezi. Van: Van Yüzüncü Yıl Üniversitesi, Sağlık Bilimleri Enstitüsü, Cerrahi (Veterinerlik) Ana Bilim Dalı; 2018.
Kamil S, Mohan RR. Corneal stromal wound healing: Major regulators and therapeutic targets. The ocular surface. 2021; 19: 290-306.
Maggs DJ, Miller PE, Ofri R. Slatter's Fundamentals of Veterinary Ophthalmology (6th ed). Canada: Elsevier Health Sciences; 2018. p. 215-33.
Can ÜK. ''Tavşanlarda Deneysel Kornea Defektlerinin Sağaltımı Üzerine Konsantre Büyüme Faktörü ve Trombositten Zengin Fibrinin Etkinliğinin Karşılaştırılması''. Elazığ: Fırat Üniversitesi, Sağlık Bilimleri Enstitüsü, Veterinerlik Cerrahisi Ana Bilim Dalı; 2023.
Can HN. ''Tavşanlarda Deneysel Olarak Oluşturulan Kemik Defektlerinin Iyileşmesi Üzerinde Değişik Greft Materyalleri ve Trombositten Zengin Fibrin'in Etkilerinin İncelenmesi''. Elazığ: Fırat Üniversitesi, Sağlık Bilimleri Enstitüsü, Veterinerlik Cerrahisi Ana Bilim Dalı; 2013.
El-shafey SA, El-Mezyen AE-mF, Behery AS, Abd El Raouf M. Comparing efficacy of the platelet rich plasma and advanced platelet rich fibrin on tibial bone defect regeneration in dogs. Iraqi Journal of Veterinary Sciences. 2022; 36(4): 973-980.
Kazemi D, Asenjan KS, Dehdilani N, Parsa H. Canine articular cartilage regeneration using mesenchymal stem cells seeded on platelet rich fibrin: Macroscopic and histological assessments. Bone & Joint Research. 2017; 6(2): 98-107.
Kazemi D, Fakhrjou A. Leukocyte and platelet rich plasma (L-PRP) versus leukocyte and platelet rich fibrin (L-PRF) for articular cartilage repair of the knee: a comparative evaluation in an animal model. Iranian Red Crescent Medical Journal. 2015; 17(10).
Abbas IA, Naeem LA, Al-Tameemi HM. Study the Effect of Sodium Hyaluronate and Autologous Platelet Rich Fibrin on Symphysis Fracture Healing in Cat. Basrah Journal of Veterinary Research. 2023; 22(4): 37-46.
Visser LC, Arnoczky SP, Caballero O, Gardner KL. Evaluation of the use of an autologous platelet-rich fibrin membrane to enhance tendon healing in dogs. American journal of veterinary research. 2011; 72(5): 699-705.
To M, Su C-y, Hidaka K, Okudera T, Matsuo M. Effect of advanced platelet-rich fibrin on accelerating alveolar bone formation in dogs: a histological and immunofluorescence evaluation. Anatomical Science International. 2019; 94: 238-244.
Kornsuthisopon C, Pirarat N, Osathanon T, Kalpravidh C. Autologous platelet-rich fibrin stimulates canine periodontal regeneration. Scientific reports. 2020; 10(1): 1850.
Tawfik HE, Abu-Seida AM, Hashem AA, El-Khawlani MM. Treatment of experimental furcation perforations with mineral trioxide aggregate, platelet rich plasma or platelet rich fibrin in dogs’ teeth. Experimental and Toxicologic Pathology. 2016; 68(6): 321-327.
Soares CS, Barros LC, Saraiva V, Gomez-Florit M, Babo PS, Dias IR, et al. Bioengineered surgical repair of a chronic oronasal fistula in a cat using autologous platelet-rich fibrin and bone marrow with a tailored 3D printed implant. Journal of feline medicine and surgery. 2018; 20(9): 835-843.
Soares CS, Dias IR, Pires MA, Carvalho PP. Effects of autologous platelet-rich fibrin (PRF) therapy on wound healing in dogs. 2022 March. DOİ:https://doi.org/10.21203/rs.3.rs-1409109/v1
Changrani-Rastogi A, Swadi K, Barve M, Bajekal N. Autologous platelet-rich fibrin promotes wound healing in cats. Frontiers in Veterinary Science. 2023; 10: 1180447.
Soares CS, Dias IR, Pires MA, Carvalho PP. Canine-origin platelet-rich fibrin as an effective biomaterial for wound healing in domestic cats: A preliminary study. Veterinary Sciences. 2021; 8(10): 213.
Raffea NM, Allawi AH. Effect of autologous peritoneum and platelet-rich fibrin graft on healing of intestinal anastomosis in dogs. Iraqi Journal of Veterinary Sciences. 2022; 36(2): 459-470.
Khanzadeh Alishahi M, Kazemi D, Mohajeri D, Mofidpoor H, Afkhami Goli A, Khanzadeh Alishahi MA. Histopathological evaluation of the effect of platelet-rich fibrin on canine cutaneous incisional wound healing. Iranian Journal of Veterinary Science and Technology. 2013; 5(2): 19-32.
Warin R, Vongchan P, Suriyasathaporn W, Boripun R, Suriyasathaporn W. In vitro assessment of lyophilized advanced platelet-rich fibrin from dogs in promotion of growth factor release and wound healing. Veterinary Sciences. 2022; 9(10): 566.
McLellan J, Plevin S. Temporal Release of Growth Factors from Platelet-rich Fibrin (PRF) and Platelet-rich Rlasma (PRP) in the Horse: A Comparative in vitro Analysis. International Journal of Applied Research in Veterinary Medicine. 2014; 12(1).
Visser LC, Arnoczky SP, Caballero O, Egerbacher M. Platelet‐rich fibrin constructs elute higher concentrations of transforming growth factor‐β1 and increase tendon cell proliferation over time when compared to blood clots: a comparative in vitro analysis. Veterinary Surgery. 2010; 39(7): 811-817.
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