The Importance of Turmeric in Ischemia/Reperfusion
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https://doi.org/10.5281/zenodo.10445899Keywords:
Turmeric, curcumin, Ischemia/Reperfusion, anti-inflammatoryAbstract
Ischemia is the inability to meet the oxygen and other metabolites required for the tissue by the circulation due to insufficient perfusion and the resulting waste products cannot be removed from there by circulation. Reperfusion; after ischemia caused by bleeding, cardiac arrest, vascular, shock, hepatic and other surgeries; blood flow, O2 and nutrients return. However, free oxygen radicals that occur when molecular oxygen enters the cell during reperfusion cause more damage than ischemia. Turmeric; It has many antioxidant, antimicrobial, antimutogenic, anti-inflammatory, antimetastatic, anticarcinogenic, angiogenesis-enhancing and neuroprotective properties. It has been determined that the powder created by drying and grinding the rhizomes of turmeric contains 2-8% curcumin, 2.5-5% essential oil and 25-70% starch. Curcuminoids, the main component of turmeric; It contains curcumin (diferuloyl methane), bisdemethoxycurcumin and demethoxycurcumin components. Curcumin, which has a polyphenol structure, facilitates the elimination of free oxygen radicals and blocks lipid peroxidation. It is known that curcumin has potential benefits in preventing many diseases such as myocardial infarction, cardiovascular diseases, arthritis, diabetes and cancer. Therefore, in this review, the effect of turmeric on ischemia/reperfusion is mentioned. Studies suggest that turmeric may be protective against cardiovascular diseases due to its anti-inflammatory, anti-coagulant, hypolipidemic, antiplatelet, antiproliferative, membrane stabilizing effects and effects on Ca+2 homeostasis.
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