Genotoxicity of Quizalofop-p-Ethyl on Vicia faba root cells Micronucleus Induction and Mitotic index
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https://doi.org/10.5281/zenodo.7130682Keywords:
Quizalofop-p-ethyl (C19H17ClN2O4-QPE), Vicia faba, Micronucleus, mitotic index, genotoxicity, cytotoxicityAbstract
Quizalofop-p-ethyl (C19H17ClN2O4-QPE) is a widely used herbicide for controlling annual and perennial grass weeds in broad-leaved agricultural crops. In this study, the effect of Quizalofob-P-Ethyl (QPE), which is used as a herbicide, on mitosis and micronuclei formation in Vicia faba root meristem cells was investigated. In this study, 5 different experimental sets as negative control (distilled water), positive control (cyclophosphomide-5mM) and three different doses of QPE (1.5mg/L, 3mg/L and 5mg/L) were used as the experimental group. Bean seeds of the same size were used as test material. QPE induced the MN formation in V.faba. It is observed that the increase in MN frequency and decrease in the MI are dose-dependent. There is a statistically significant difference between treatment and control groups (P <0.05 and p<0.01 for 3 mg/mL and 5 mg/ml respectively) for MN frequency. Results of our study indicate that QPE may produce genotoxic effects in plants. In addition, plant bioassays as the results of the majority of in vivo/in vitro mammalian tests are comparable, they are sensitive indicators for genotoxicity assessment.
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