CLINICAL FACTORS PREDICTING RESPONSE TO REGORAFENIB IN METASTATIC COLORECTAL CANCER

Abstract

Colorectal cancer (CRC) is a common disease with high mortality. Regorafenib (Stivarga ®) is an oral small molecule, multiple kinase inhibitor approved worldwide for use in metastatic colorectal cancer. In our study, clinical factors predicting response to regorafenib were investigated. Patients who applied to Gaziantep Medical Park Hospital and Sanko University Medical Faculty Hospital Medical Oncology outpatient clinic between 2010-2021 with the diagnosis of mCRC and using regorafenib were included in the study. Electronic medical records of the patients were reviewed retrospectively. Statistical analyzes were performed using SPSS version 15.0 software. A total of 20 patients with metastatic colorectal cancer using regorafenib in the third or fourth line therapy were included in the study. Overall, 15 (75%) patients had liver metastases. The median overall survival of the patients was 25.5 months (95% Confidence Interval (CI), 24.1-26.8). Overall survival was not significantly associated with sex, ECOG performance status score, de novo metastatic disease status, smoking status and weight loss history (p=0.139, p=0.240, p=0.173, p=0.911, p=0.923, respectively). A significant association was found between the presence of liver metastasis and survival (p=0.036). The median overall survival was 40.3 months (95% CI, 0-92.6) in patients without liver metastases, and 25 months (95% CI: 13.8-36.2) in patients with liver metastases. In this retrospective study investigating the factors affecting the survival of patients using regorafenib with the diagnosis of mCRC, the presence of liver metastasis was found to be associated with a poor prognosis.