THE IMPORTANCE OF ADIPOCYTOKINE SIGNAL PATHWAYS

Abstract

Adipocytokines are bioactive mediators produce by white adipose tissue and affecting cell regulation, signaling, function, inflammation, etc. They act mainly immune functions and inflammatory processes. Leptin, Ghrelin, Adiponectin, Resistin, Visfatin, Omentin, Apelin, Chemerin, Nesfatin are among the most widely studied in adipocytokines. Adipocytokines' essential effects in many diseases such as cardiovascular diseases, neurological diseases, and metabolic diseases have been shown. Recent insights have now revealed how adipocytokine is activated during inflammation or diseases, the molecular mechanism for structure and effects on pro-/anti-inflammatory cytokines, and various adipocytokines in the monocytes-macrophage system incredibly immune system and linked diseases. Moreover, many studies are investigating whether adipocytokines are risk factors for many diseases. These results suggest that the mechanisms of action of other newly defined adipocytokines and the effects of target tissues on various diseases should be investigated in detail with molecular and experimental, even human studies.