Primer Baş Ağrısı Olan Hastalarda Homosistein Folik Asit, Vit B12 ve Eser Element Düzeylerinin Değerlendirilmesi
Özet Görüntüleme: 39
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DOI:
https://doi.org/10.5281/zenodo.13884512Anahtar Kelimeler:
Primer baş ağrısı , Homosistein, Folik asid, Vitaminler, Eser elementlerÖzet
Primer baş ağrısının bir çok tipi vardır. Homosistein oksidatif strese neden olmaktadır. B12 vitamini ve folik asit azalması hiperhomosisteinemiye yol açmaktadır. Çinkonun oksidatif strese karşı koruyucu, bakırın ise oksidatif strese neden olduğu gösterilmiştir. Bu çalışma primer baş ağrısı olan hastalarda oksidatif hasara neden olan homosistein ve B12 vitamini, folik asit, çinko, bakır düzeylerindeki değişiklikleri belirlemeyi ve bu parametrelerin hastalığın etiyolojisine katkısını saptamayı amaçlamıştır. Çalışmaya 30 primer baş ağrısı tanısı almış hasta (Grup I) ve 30 tamamen sağlıklı birey (Grup II) olmak üzere toplam 60 kişi dahil edildi. Çalışmadaki gruplar arasında serum homosistein, folik asit, B12 vitamini, çinko ve bakır düzeyleri karşılaştırıldı. Grup I'de homosistein düzeylerinde istatistiksel olarak anlamlı artış (p<0,05), folik asit düzeylerinde ise istatistiksel olarak anlamlı azalma (p<0,05) gözlendi. Vitamin B12, çinko ve bakır düzeylerinde gruplar arasında istatistiksel olarak anlamlı fark bulunmadı (p>0,05). Primer baş ağrısı olan hastalarda, homosistein ve folik asit düzeylerinin etiyolojide rol oynayabileceğini ve folik asit’in tedavide kullanılabileceğini düşünmekteyiz.
Referanslar
Bartłomiej Błaszczyk, Marcin Straburzyński, Mieszko Więckiewicz, Sławomir Budrewicz, Piotr Niemiec, Martyna Staszkiewicz and Marta Waliszewska‑Prosół. Relationship between alcohol and primary headaches: a systematic review and meta-analysis
Messoud Ashina and Cenk Ayata. Neurovascular origin of primary headaches. Journal of Cerebral Blood Flow & Metabolism 2019, Vol. 39(4) 571–572.
Jairo Hernandez, Eduardo Molina, Ashley Rodriguez, Samuel Woodford, Andrew Nguyen, Grace Parker Brandon Lucke-Wold. Headache Disorders: Differentiating Primary and Secondary Etiologies. J. Integr. Neurosci. 2024; 23(2):43.
Majumder A, Singh M, George AK, Tyagi SC. Restoration of skeletal muscle homeostasis by hydrogen sulfide during hyperhomocysteinemia-mediated oxidative/ER stress condition 1. Can J Physiol Pharmacol. 2019 Jun;97(6):441-456.
Ganguly P, Alam SF. Role of homocysteine in the development of cardiovascular disease Nutr J. 2015;14:6.
Perna AF, Ingrosso D. Homocysteine and chronic kidney disease: an ongoing narrative. J Nephrol. 2019;32(5):673-675.
Rebecca L. Wilson, Jessica A. Grieger, Tina Bianco-Miotto and Claire T. Roberts. Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications:A Systematic Review. Nutrients 2016, 8, 641.
Yueqin Li. Copper homeostasis: Emerging target for cancer treatment. IUBMB Life. 2020;72:1900–1908.
Stovner LJ, Hagen K, Linde M, Steiner TJ (2022) The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates. J Headache Pain 23:34
Burch R (2019) Migraine and Tension‑Type Headache: Diagnosis and Treatment. Med Clin North Am 103:215–233.
GBD 2017 US Neurological Disorders Collaborators, Feigin VL, Vos T, Alahdab F, Amit AML, Bärnighausen TW, et al. Burden of Neurological Disorders Across the US From 1990–2017: A Global Burden of Disease Study. JAMA Neurol 2021;78:165–76.
Al‑Karagholi MA, Peng K‑P, Petersen AS, De Boer I, Terwindt GM, Ashina M (2022) Debate: Are cluster headache and migraine distinct head‑ ache disorders? J Headache Pain 23:151.
Borkum JM. Migraine triggers and oxidative stress: a narrative review and synthesis. Headache (2016) 56(1):12–35.
Dong X, Guan X, Chen K, Jin S, Wang C, Yan L, et al. Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine. Neurosci Lett (2017) 636:127–33.
Malhotra R. Understanding migraine: potential role of neurogenic inflammation. Ann Indian Acad Neurol (2016) 19(2):175–82.
Škovierová, H.; Vidomanová, E.; Mahmood, S.; Sopková, J.; Drgová, A.; Cerve ˇnov ˇ á, T.; Halasova, E.;Lehotský, J. The molecular and cellular effect of homocysteine metabolism imbalance on human health. Int. J.Mol. Sci. 2016, 17, 1733.
Strauss, E.; Supinski, W.; Radziemski, A.; Oszkinis, G.; Pawlak, A.L.; Gluszek, J. Is hyperhomocysteinemia a causal factor for heart failure? The impact of the functional variants of MTHFR and PON1 on ischemic and non-ischemic etiology. Int. J. Cardiol. 2017, 228, 37–44.
Esse, R.; Barroso, M.; De Almeida, I.T.; Castro, R. The contribution of homocysteine metabolism disruption to endothelial dysfunction: state-of-the-art. Int. J. Mol. Sci. 2019, 20, 867.
Sadeghvand SH, Barzegar M, Shiva S, Tarmahi V, Khodaie H, Rahimi Khamaneh E, Golchinfar z, Raeisi S . The Effects of Vitamin B-Complex Supplementation on Serum Homocysteine Levels and Migraine Severity in Children: A Randomized Controlled Trial. Iran J Child Neurol. Summer 2023; 17 (3): 143-155.
Liampas, I.; Siokas, V.; Mentis, A.A.; Aloizou, A.M.; Dastamani, M.; Tsouris, Z.; Aslanidou, P.; Brotis, A.; Dardiotis, E. Serum homocysteine, pyridoxine, folate, and vitamin B12 levels in migraine: Systematic review and meta-analysis. Headache 2020, 620, 1508–1534.
13. Esse, R.; Barroso, M.; De Almeida, I.T.; Castro, R. The contribution of homocysteine metabolism disruption to endothelial dysfunction: state-of-the-art. Int. J. Mol. Sci. 2019, 20, 867.
Mehmet Semih Demirtas, and Huseyin Erdal. Evaluation of thiol disulfide balance in adolescents with vitamin B12 deficiency Italian Journal of Pediatrics (2023) 49:3.
16. Yulia Shulpekova, Vladimir Nechaev, Svetlana Kardasheva, Alla Sedova, Anastasia Kurbatova, Elena Bueverova, Arthur Kopylov, Kristina Malsagova, Jabulani Clement Dlamini, Vladimir Ivashkin. The Concept of Folic Acid in Health and Disease.
Saras Menon, Bushra Nasir, Nesli Avgan, Sussan Ghassabian, Christopher Oliver, Rodney Lea, Maree Smith and Lyn Griffith. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patientsThe Journal of Headache and Pain (2016) 17:60.
Sibel Üstün Özek. A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine. Arq Neuropsiquiatr 2022;80(6):586-592.
S. Choi, X. Liu, Z. Pan, Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases, Acta Pharmacol. Sin. 39 (7) (2018) 1120–1132.
Nattagh-Eshtivani E, Sani MA, Dahri M, Ghalichi F, Ghavami A, Arjang P, Tarighat-Esfanjani A. The role of nutrients in the pathogenesis and treatment of migraine headaches: review. Biomed Pharmacother 2018;102:317-25.
Cikim G, İzgi K, Kilinc M, Çelik A, Karaveli Ç, Karaveli A, et al. Trace elements and oxidant-
antioksidant levels in the etiology of indirect inguinal hernia. Trace elements and Electrolytes.
;33(1):8-12.
Zhuoying Chen , Yuan-yuan Li , Xiangjie Liu Copper homeostasis and copper-induced cell death： Novel targeting for intervention in the pathogenesis of vascular aging. Biomedicine & Pharmacotherapy 169 (2023) 115839
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