EFFICACY OF N-ACETYLCYSTEINE TREATMENT IN METHIMAZOLE-INDUCED MYOPATHY AND TOXIC HEPATITIS (CASE REPORT)


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Authors

  • Tahir Buran Department of Gastroenterology, Manisa Celal Bayar University
  • Mustafa Sahin Department of Internal Medicine, Manisa Celal Bayar University
  • Elmas Kasap Department of Gastroenterology, Manisa Celal Bayar University
  • Semin Ayhan Department of Pathology, Faculty of Medicine, Manisa Celal Bayar University
  • Burcu Almacan Department of Internal Medicine, Manisa Celal Bayar University

DOI:

https://doi.org/10.38065/euroasiaorg.230

Keywords:

Hyperthyroidism, Myalgia, Creatine kinase, Liver injury, Elevated liver enzymes, icterus

Abstract

Today, antithyroid drugs are widely used in the treatment of hyperthyroidism. Elevated creatine kinase and liver injury (hepatitis) caused by methimazole are some of rare side effects. Elevation of creatine kinase (CK) should be monitored due to the risk of rhabdomyolysis development. Also, drug-induced liver injury can be seen. In this article, we report a patient who was put on methimazole 2 months ago for hyperthyroidism, but then began to have complaints about muscle pain, jaundice (icterus) in the eyes along with itching and dark urine, and found out to have elevated creatine kinase as well as liver enzymes induced by liver injury, thus showed rapid recovery upon N-Acetyl Cysteine (NAC) treatment.

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Published

2020-09-30

How to Cite

Buran, T., Sahin, M., Kasap, E., Ayhan, S., & Almacan, B. (2020). EFFICACY OF N-ACETYLCYSTEINE TREATMENT IN METHIMAZOLE-INDUCED MYOPATHY AND TOXIC HEPATITIS (CASE REPORT). Euroasia Journal of Mathematics, Engineering, Natural & Medical Sciences, 7(11), 44–51. https://doi.org/10.38065/euroasiaorg.230

Issue

Vol. 7 No. 11 (2020)

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.