Nanocarrier Systems for Violacein Delivery
DOI:
https://doi.org/10.5281/zenodo.17101821Anahtar Kelimeler:
Violacein, Drug Delivery, NanocarrierÖzet
Violacein is a natural microbial pigment predominantly produced by Chromobacterium violaceum, notable for its broad spectrum of biological activities. Despite its antibacterial, antifungal, antiviral, anticancer, antiparasitic, and immunomodulatory properties, its hydrophobic nature and poor aqueous solubility represent major limitations to its bioavailability. Nanotechnological drug delivery systems have provided significant advances in overcoming these challenges. The literature reports numerous studies in which violacein has been incorporated into polymeric, lipid-based, metallic, and hybrid nanocarrier systems, leading to improved bioavailability, reduced toxicity, and enhanced controlled release profiles. Furthermore, synergistic antibacterial and anticancer effects have been achieved. This review summarizes the pharmaceutical potential of violacein, its solubility limitations, and the advantages conferred by nanotechnological carrier systems.
Referanslar
Aires-Lopes, B., Coleborn, E., Souza-Fonseca-Guimarães, F., & Ferreira-Halder, C. V. (2025). Antitumor activity of violacein in osteosarcoma, neuroblastoma and triple-negative breast cancer spheroids. Toxicon, 265, 108501.
Arif, S., Batool, A., Khalid, N., Ahmed, I., & Janjua, H. A. (2017). Comparative analysis of stability and biological activities of violacein and starch capped silver nanoparticles. RSC Advances, 7(8), 4468–4478.
Asencio, G., Lavin, P., Alegría, K., Domínguez, M., Bello, H., González-Rocha, G., & González-Aravena, M. (2014c). Antibacterial activity of the Antarctic bacterium Janthinobacterium sp. SMN 33.6 against multi-resistant Gram-negative bacteria. Electronic Journal of Biotechnology, 17(1), 1–5.
Berni, E., Marcato, P. D., Nakazato, G., Kobayashi, R. K. T., Vacchi, F. I., Umbuzeiro, G. A., & Durán, N. (2013). Violacein/poly(ϵ-caprolactone)/chitosan nanoparticles against bovine mastistis: Antibacterial and ecotoxicity evaluation. Journal of Physics: Conference Series, 429(1), 012030.
Berti, I. R., Rodenak-Kladniew, B., Perez, A. A., Santiago, L., Duran, N., & Castro, G. R. (2019). Development of biocarrier for violacein controlled release in the treatment of cancer. Reactive and Functional Polymers, 136, 122–130.
Bilici, E., Akgün, EE, Akkoç, S., 2025. Comparative Evaluation of the Apoptosis Effect of a Benzimidazole-Based Compound and Cisplatin in DLD-1 and MDA-MB-231 Cell Lines. Euroasia 12(1): 140-146,
Bilici, E., Akkoç, S., 2025. Investigation of the Cytotoxic Effect of A New NPhenyl Benzimidazole Derivative on Cell Viability in A549 and HepG2 Cell Lines. Van Med J 32 (1): 3-6.
Bilici, E., Uğuz, C., Altunbaş, K., 2025. Examining the Impact of 4-Nonylphenol on G-361 Malignant Melanoma Cell Proliferation and Apoptosis Activation, Van Vet J, 2025, 36 (2) 110-114.
Chamundeeswari, M., Jeslin, J., & Verma, M. L. (2018). Nanocarriers for drug delivery applications. Environmental Chemistry Letters 2018 17:2, 17(2), 849–865.
Choi, S. Y., Lim, S., Cho, G., Kwon, J., Mun, W., Im, H., & Mitchell, R. J. (2020). Chromobacterium violaceum delivers violacein, a hydrophobic antibiotic, to other microbes in membrane vesicles. Environmental Microbiology, 22(2), 705–713.
Choi, S. Y., Yoon, K. H., Lee, J. Il, & Mitchell, R. J. (2015). Violacein: Properties and Production of a Versatile Bacterial Pigment. BioMed Research International, 2015.
de Carvalho, D. D., Costa, F. T. M., Duran, N., & Haun, M. (2006). Cytotoxic activity of violacein in human colon cancer cells. Toxicology in Vitro, 20(8), 1514–1521.
Durán, N., Fávaro, W. J., Brocchi, M., Justo, G. Z., Castro, G. R., Durán, M., & Nakazato, G. (2021). Patents on violacein: A compound with great diversity of biological activities and industrial potential. Recent Patents on Biotechnology, 15(2), 102–111.
Durán, N., Justo, G. Z., Ferreira, C. V., Melo, P. S., Cordi, L., & Martins, D. (2007). Violacein: properties and biological activities. Biotechnology and Applied Biochemistry, 48(3), 127–133.
Durán, N., Justo, G. Z., Melo, P. S., De Azevedo, M. B. M., Souza Brito, A. R. M., Almeida, A. B. A., & Haun, M. (2003). Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with β-cyclodextrin. Canadian Journal of Physiology and Pharmacology, 81(4), 387–396.
Fakhr, F. A., Khanafari, A., Baserisalehi, M., Yaghoobi, R., & Shahghasempour, S. (2012). An investigation of antileukemia activity of violacein-loaded dendrimer in Jurkat cell lines. African Journal of Microbiology Research, 6(33), 6235–6242.
Gao, A., Chen, H., Hou, A., & Xie, K. (2019). Efficient antimicrobial silk composites using synergistic effects of violacein and silver nanoparticles. Materials Science and Engineering: C, 103, 109821.
Gimenez, I. F., Anazetti, M. C., Melo, P. S., Haun, M., De Azevedo, M. M. M., Durán, N., & Alves, O. L. (2006b). Cytotoxicity on V79 and HL60 Cell Lines by Thiolated--Cyclodextrin-Au/Violacein Nanoparticles. Journal of Biomedical Nanotechnology, 1(3), 352–358.
Hamzah, M. A. A. M., Rusdi, N. A., Wahidin, M. A., Aruldass, C. A., Maarof, H., Ahmad, W. A., & Setu, S. A. (2024). Synthesis of water-soluble violacein nanoparticles and molecular dynamic study. Colloid and Polymer Science, 302(5), 791–802.
Kanelli, M., Saleh, B., Webster, T. J., Vouyiouka, S., & Topakas, E. (2022). Co-Encapsulation of Violacein and Iron Oxide in Poly(lactic acid) Nanoparticles for Simultaneous Antibacterial and Anticancer Applications. Journal of Biomedical Nanotechnology, 18(3), 729–739.
Kodach, L. L., Bos, C. L., Durán, N., Peppelenbosch, M. P., Ferreira, C. V., & Hardwick, J. C. H. (2006). Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells. Carcinogenesis, 27(3), 508–516.
Leelaudomlipi, P., Intawong, S., Supakdamrongkul, P., & Sobharaksha, P. (2021). Preparation of Nanostructured Lipid Carriers (NLCs) Loading Violacein Extract for Anti-Acne Products. Key Engineering Materials, 901, 129–136.
Martins, D., Costa, F. T. M., Brocchi, M., & Durán, N. (2011). Evaluation of the antibacterial activity of poly-(d,l-lactide-co-glycolide) nanoparticles containing violacein. Journal of Nanoparticle Research, 13(1), 355–363.
Martins, D., Frungillo, L., Anazzetti, M. C., Melo, P. S., & Durán, N. (2010). Antitumoral activity of L-ascorbic acid-poly-D, L-(lactide-co-glycolide) nanoparticles containing violacein. International Journal of Nanomedicine, 5(1), 77–85.
Matz, C., Webb, J. S., Schupp, P. J., Phang, S. Y., Penesyan, A., Egan, S., Steinberg, P., & Kjelleberg, S. (2008). Marine Biofilm Bacteria Evade Eukaryotic Predation by Targeted Chemical Defense. PLOS ONE, 3(7), e2744.
Mishra, B., Patel, B. B., & Tiwari, S. (2010). Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nanomedicine: Nanotechnology, Biology and Medicine, 6(1), 9–24.
Mohd Yatim, H., Arul Aruldass, C., Amir Asyraf Mohd Hamzah, M., Azlina Ahmad, W., & Aminah Setu, S. (2019). Synthesis and optimization of nano-sized bacterial-based violacein pigment using response surface methodology. / Malaysian Journal of Fundamental and Applied Sciences, 15(6), 818–824.
Nakazato, G., Gonçalves, M. C., da Silva das Neves, M., Kobayashi, R. K. T., Brocchi, M., & Durán, N. (2019). Violacein@Biogenic Ag system: synergistic antibacterial activity against Staphylococcus aureus. Biotechnology Letters, 41(12), 1433–1437.
Park, H. A., Park, S. A., Yang, Y. H., & Choi, K. Y. (2021). Microbial synthesis of violacein pigment and its potential applications. Critical Reviews in Biotechnology, 41(6), 879–901.
Qian, W. Y., Sun, D. M., Zhu, R. R., Du, X. L., Liu, H., & Wang, S. L. (2012). pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release. International Journal of Nanomedicine, 7, 5781–5792.
Rahul, S., Chandrashekhar, P., Hemant, B., Bipinchandra, S., Mouray, E., Grellier, P., & Satish, P. (2015b). In vitro antiparasitic activity of microbial pigments and their combination with phytosynthesized metal nanoparticles. Parasitology International, 64(5), 353–356.
Rivero Berti, I., Gantner, M. E., Rodriguez, S., Islan, G. A., Fávaro, W. J., Talevi, A., Castro, G. R., & Durán, N. (2023). Potential biocide roles of violacein. Frontiers in Nanotechnology, 5, 1186386.
Sun, T., Shrike Zhang, Y., Bo, P., Hyun, D. C., Yang, M., & Xia, Y. (2021). Engineered Nanoparticles for Drug Delivery in Cancer Therapy*. Nanomaterials and Neoplasms, 31–142.
İndir
Yayınlanmış
Nasıl Atıf Yapılır
Sayı
Bölüm
Lisans
Telif Hakkı (c) 2025 Euroasia Matematik, Mühendislik, Doğa ve Tıp Bilimleri Dergisi Medical Sciences
Bu çalışma Creative Commons Attribution-NonCommercial 4.0 International License ile lisanslanmıştır.
Dergimizde yayımlanan makaleler, 