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Abstract


AN IMPORTANT ACTOR IN CARCINOGENESIS: PHOSPHATIDYLINOCITOL-3 KINASE SIGNAL PATH

The events of cell division and growth, proliferation, apoptosis, invasion and metastasis, which are important in cancer formation and progression, are regulated by various cell signaling pathways. In this process, mutations and epigenetic changes in genes that regulate the coding of important proteins play a role in cancer formation. Many important changes such as mutations in proteins related to cell division and control, hyperactivation of many signaling pathways activated by growth factors, inactivation of tumor suppressor genes cause uncontrolled cell proliferation and cancer development. Self-sufficiency of cancer cells in growth factors, loss of cell cycle control, escape from apoptosis, unlimited and uncontrolled proliferation, angiogenesis, invasion and metastasis are supported by signaling pathways. In this review, the phosphoainositidylinositol-3 kinase signaling pathway, which plays an important role in cancer formation, progression and metastasis, and the identification of important molecules in this pathway and their roles in malignant transformation; In addition, it is aimed to statistically support the importance of genetic and epigenetic changes occurring in this signal pathway with current cancer data. The possible role of molecules in the phosphoainositidylinositol-3 kinase signaling pathway as early prognostic and/or therapeutic targets in cancer will be highlighted.



Keywords
Cancer, apoptosis, mutation, phosphatidylinositol-3-kinase, epigenetics, protooncogene



Kaynakça Manning, B. D. and A. Toker (2017). "AKT/PKB signaling: navigating the network." Cell169(3): 381-405.

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