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Abstract


PROGNOSTIC VALUE OF CEA, CA 19-9, CA 15-3, CA 125 AND AFP TUMOR MARKERS IN GASTROINTESTINAL AND BREAST MALIGNANT NEOPLASM PREOPERATIVE PATIENTS

Biomarkers now play an important role in the detection and treatment of patients with gastrointestinal and breast malignant carcinoma. For this purpose, we investigated the main tumor markers CEA, CA 19-9, CA 15-3, CA 125 and AFP levels in preoperative patients, their prognostic significance and their relationships. Materials and Methods: CEA of 168 patients, 72 male and 96 female, diagnosed with preoperative gastrointestinal malignant neoplasm (colon, colorectal, rectum, secum, ileum, stomach and pancreas) and breast malignant neoplasm between October 2019 and December 2019, CA 19-9, CA 15-3, CA 125 and AFP test results were analyzed retrospectively. Results: Of 102 preoperative patients with gastrointestinal malign neoplasm included in the study, 72 were male (61%) and 30 were female (29%). In this patient group, 20 stomach, 45 colon, 12 rectum, 6 secum, 8 pancreas, 5 liver, 6 There were patients with malignant neoplasm of the duodenum (Table 2). The mean age of male patients was 63.1 ± 9.3, and the mean age of female patients was 66.3 ± 9.8. Conclusion:We concluded that in patients with gastrointestinal malignant neoplasm, the CEA tumor biomarker is an independent prognostic factor independent of CA 19-9 and AFP tests, while in preoperative patients with breast malignant neoplasm, CEA levels correlate consistent with the tumor biomarkers CA 15-3, CA 125.



Keywords
EGTM; tumormarkers; colorectal cancer; gastrointestinal cancer; breast cancer.



Kaynakça 1. Chan CC, Fan CW, Kuo YB, Chen YH, Chang PY, Chen KT, Hung RP, Chan EC. Multiple serological biomarkers for colorectal cancer detection. Int J Cancer. 2010;126:1683–90. 2. Al-Shuneigat JM, Mahgoub SS, Huq F. Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and ca 19-9 as apoptotic markers; a comparative study. J Biomed Sci. 2011;18:50. 3. Swiderska M, Choromanska B, Dabrowska E, Konarzewska-Duchnowska E, Choromanska K, Szczurko G, Mysliwiec P, Dadan J, Ladny JR, Zwierz K. The diagnostics of colorectal cancer. Contemp Oncol (Pozn) 2014;18:1–6. 4. Sajid KM, Parveen R, Durr-e-Sabih , Chaouachi K, Naeem A, Mahmood R, Shamim R. Carcinoembryonic antigen (CEA) levels in hookah smokers, cigarette smokers and non-smokers. J Pak Med Assoc. 2007;57:595–9. 5. Zheng CX, Zhan WH, Zhao JZ, Zheng D, Wang DP, He YL, Zheng ZQ. The prognostic value of preoperative serum levels. World J Gastroenterol. 2001;7:431–4. 6. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5–29. 7. Stiksma J, Grootendorst DC, van der Linden PW. CA 19-9 As a Marker in Addition to CEA to Monitor Colorectal Cancer. Clin Colorectal Cancer. 2014;13:239–44.

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